We are running SQL Server 2000. I can take all databases offline in SQL
Server Enterprise Manager except once. The option is not even there on
the menu for that database. Does anyone know why this would happen?

I tried to detach instead and it said I can't detach while the database
is being replicated. From what I can tell though that actually isn't
the case. Also I have tried this different days and I still get the
same message. I think something else is going on. Any ideas?

could try the following from qa.

alter database mydb
set offline

could try the following from qa.

alter database mydb
set offline